{"id":605,"date":"2023-12-14T15:35:48","date_gmt":"2023-12-14T15:35:48","guid":{"rendered":"https:\/\/montdorex.com\/?page_id=605"},"modified":"2024-04-30T03:40:55","modified_gmt":"2024-04-30T03:40:55","slug":"accueil","status":"publish","type":"page","link":"https:\/\/montdorex.com\/fr\/","title":{"rendered":"Accueil"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row content_placement=\u00a0\u00bbmiddle\u00a0\u00bb parallax=\u00a0\u00bbcontent-moving\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1698847106223{margin-top: -50px !important;padding-top: 0px !important;padding-bottom: 100px !important;background-position: center;background-repeat: no-repeat !important;background-size: cover !important;}\u00a0\u00bb][vc_column][vc_single_image image=\u00a0\u00bb741&Prime; img_size=\u00a0\u00bbfull\u00a0\u00bb onclick=\u00a0\u00bbcustom_link\u00a0\u00bb css=\u00a0\u00bb\u00a0\u00bb link=\u00a0\u00bbhttp:\/\/www.montdorex.com\/fr\/publications\u00a0\u00bb][info_banner_vc google_fonts=\u00a0\u00bbfont_family:Abril%20Fatface%3Aregular|font_style:400%20regular%3A400%3Anormal\u00a0\u00bb image_id=\u00a0\u00bb577&Prime;][\/info_banner_vc]<div class=\"mgt-header-block clearfix text-left text-custom wpb_content_element  mgt-header-block-style-1 mgt-header-block-fontsize-regular mgt-header-texttransform-none mgt-header-block-33813998 \"><h2 class=\"mgt-header-block-title text-font-weight-100\">\u00c0 propos de Montdorex<\/h2><\/div><style scoped='scoped'>.mgt-header-block-33813998.mgt-header-block .mgt-header-block-title {color: #2a3390!important;}<\/style>[vc_column_text]<span style=\"color: #000000; font-size: 18px;\">\u00c9tablie \u00e0 Montr\u00e9al, au Canada, Montdorex Inc. est une compagnie priv\u00e9e de m\u00e9decine de pr\u00e9cision, qui cible l\u2019enzyme endo-exonucl\u00e9ase (EE) au moyen d\u2019inhibiteurs exclusifs de mono-amidine et de di-amidine contre le cancer et d\u2019analogues de di-amidine pour des applications anti-inflammatoires.<\/span><\/p>\n<p><span style=\"color: #000000; font-size: 18px;\">&#8211; <strong>En oncologie<\/strong>, l\u2019EE est pr\u00e9sente en grandes quantit\u00e9s dans les cellules canc\u00e9reuses, son r\u00f4le consistant \u00e0 r\u00e9parer les bris d\u2019ADN qui se produisent lorsque les cellules canc\u00e9reuses prolif\u00e8rent. L\u2019inhibition de cette enzyme pourrait compromettre le d\u00e9veloppement du cancer. En inhibant l\u2019enzyme EE, nous pensons que nos analogues exclusifs de pentamidine* ont le potentiel de contrecarrer le processus de r\u00e9paration de l\u2019ADN et de r\u00e9duire la capacit\u00e9 de d\u00e9veloppement de la tumeur<sup>1-5<\/sup>.<\/span><\/p>\n<p><span style=\"color: #000000; font-size: 18px;\">&#8211; <strong>Le potentiel anti-inflammatoire <\/strong>de la pentamidine est bien document\u00e9<sup>6-7 <\/sup>, mais son utilisation a \u00e9t\u00e9 compromise en raison de sa cytotoxicit\u00e9. Montdorex pense que plusieurs de ses analogues exclusifs de pentamidine** pourraient procurer des effets anti-inflammatoires notables et permettre le d\u00e9veloppement de m\u00e9dicaments non-cytotoxiques pr\u00e9sentant un profil d\u2019innocuit\u00e9 appropri\u00e9 pour des indications chroniques, non-oncologiques.<\/span><\/p>\n<p><span style=\"color: #000000; font-size: 18px;\">Nous pensons que le d\u00e9veloppement de traitements bas\u00e9s sur nos analogues propri\u00e9taires de pentamidine pourrait permettre l\u2019\u00e9mergence d\u2019agents anti-canc\u00e9reux et anti-inflammatoires am\u00e9lior\u00e9s dans ces deux grands march\u00e9s aux besoins criants de traitements innovants.<\/span>[\/vc_column_text]<div class=\"mgt-button-wrapper mgt-button-wrapper-align-left mgt-button-wrapper-display-inline mgt-button-top-margin-false mgt-button-right-margin-false mgt-button-round-edges-medium  \"><a class=\"btn hvr-default mgt-button-icon- mgt-button mgt-style-solid mgt-size-large mgt-align-left mgt-display-inline mgt-text-size-large mgt-button-icon-separator- mgt-button-icon-position-left text-font-weight-default mgt-text-transform-none mgt-button-59614854\" href=\"https:\/\/www.montdorex.com\/fr\/pipeline\">D\u00c9COUVREZ NOTRE PIPELINE<\/a><\/div><style scoped='scoped'>.mgt-button-59614854.mgt-button {background-color: #2a3390!important;}.mgt-button-59614854.mgt-button:hover {background: none!important;background-color: #1e73be!important;}.mgt-button-59614854.mgt-button {color: #ffffff!important;}.mgt-button-59614854.mgt-button:hover {color: #ffffff!important;}<\/style><div class=\"mgt-header-block clearfix text-left text-custom wpb_content_element  mgt-header-block-style-1 mgt-header-block-fontsize-regular mgt-header-texttransform-none mgt-header-block-80090610 \"><h2 class=\"mgt-header-block-title text-font-weight-100\">L\u2019opportunit\u00e9 : d\u00e9velopper une nouvelle g\u00e9n\u00e9ration d\u2019inhibiteurs de l\u2019endo-exonucl\u00e9ase<\/h2><\/div><style scoped='scoped'>.mgt-header-block-80090610.mgt-header-block .mgt-header-block-title {color: #2a3390!important;}<\/style>[vc_column_text]<strong><span style=\"color: #0c7e40; font-size: 18px;\">Processus de r\u00e9paration de l\u2019ADN<\/span><\/strong><\/p>\n<p><span style=\"color: #000000; font-size: 18px;\"><strong>L\u2019enzyme EE, qui se trouve en grandes quantit\u00e9s dans des cellules canc\u00e9reuses, a pour fonction de r\u00e9parer les bris d\u2019ADN qui surviennent lorsque les cellules canc\u00e9reuses se multiplient. L\u2019inhibition de cette enzyme pourrait bloquer la croissance tumorale. <\/strong><\/span><\/p>\n<p><span style=\"color: #000000; font-size: 18px;\">Gr\u00e2ce \u00e0 une combinaison unique d\u2019expertise interne sur l\u2019enzyme EE et la pentamidine, connue pour son activit\u00e9 sur les cellules canc\u00e9reuses, Montdorex se positionne avantageusement pour d\u00e9velopper des analogues de pentamidine afin d\u2019offrir des solutions innovantes comme th\u00e9rapies en oncologie. L\u2019efficacit\u00e9 et la pertinence du processus de r\u00e9paration de l\u2019ADN ont \u00e9t\u00e9 reconnues par l\u2019attribution conjointe du Prix Nobel de Chimie 2015 \u00e0 Tomas Lindahl, Paul Modrich et Aziz Sancar pour \u00ab les \u00e9tudes m\u00e9caniques de la r\u00e9paration de l\u2019ADN \u00bb. <\/span><\/p>\n<p><strong><span style=\"color: #0c7e40; font-size: 18px;\">Propri\u00e9t\u00e9s anti-inflammatoires<\/span><\/strong><\/p>\n<p><span style=\"color: #000000; font-size: 18px;\"><strong>L\u2019effet de la pentamidine comme agent anti-inflammatoire potentiel est bien document\u00e9. Cependant, son d\u00e9veloppement pour des applications li\u00e9es \u00e0 l\u2019inflammation est limit\u00e9e par la cytotoxicit\u00e9 qu\u2019elle cause.<\/strong><\/span><\/p>\n<p><span style=\"color: #000000; font-size: 18px;\">Notre technologie exclusive nous permet d\u2019identifier les analogues de pentamidine qui conservent une activit\u00e9 anti-inflammatoire mais r\u00e9duisent la cytotixicit\u00e9, afin d\u2019\u00e9largir l\u2019\u00e9tendue de nos recherches pour inclure les conditions gastro-intestinales (GI), ainsi que les maladies h\u00e9patiques.<\/span>[\/vc_column_text]<div class=\"mgt-button-wrapper mgt-button-wrapper-align-left mgt-button-wrapper-display-inline mgt-button-top-margin-false mgt-button-right-margin-false mgt-button-round-edges-medium  \"><a class=\"btn hvr-default mgt-button-icon- mgt-button mgt-style-solid mgt-size-large mgt-align-left mgt-display-inline mgt-text-size-large mgt-button-icon-separator- mgt-button-icon-position-left text-font-weight-default mgt-text-transform-none mgt-button-38758602\" href=\"https:\/\/www.montdorex.com\/fr\/plateforme\">D\u00c9COUVREZ NOTRE PLATEFORME<\/a><\/div><style scoped='scoped'>.mgt-button-38758602.mgt-button {background-color: #2a3390!important;}.mgt-button-38758602.mgt-button:hover {background: none!important;background-color: #1e73be!important;}.mgt-button-38758602.mgt-button {color: #ffffff!important;}.mgt-button-38758602.mgt-button:hover {color: #ffffff!important;}<\/style>[vc_column_text]<span style=\"color: #000000; font-size: 14px;\">* Analogues exclusifs de pentamidine anti-canc\u00e9reux : MTDX 203, MTDX 301 et MTDX 302<\/span><\/p>\n<p><span style=\"color: #000000; font-size: 14px;\">** Analogues exclusifs de pentamidine anti-inflammatoires : MTDX 401 et MTDX 402<\/span><\/p>\n<p><span style=\"color: #000000; font-size: 14px;\"><sup>1<\/sup>Asefa et al (1998) Curr Genet 34:360-367;\u00a0<sup>2<\/sup>Choudhury et al (2007) MCB 300:215-226;\u00a0<sup>3<\/sup>Choudhury et al (2007) MCB\u00a0 304:127-134;\u00a0<sup>4<\/sup>Choudhury et al (2007) Invest New Drugs 25:399-410;\u00a0<sup>5<\/sup>Chow et al (2003) MCT 3:911-918. <sup>6<\/sup>Zhao et al (2017) Hepatology 66:922-935;\u00a0<sup>7<\/sup>Wu et al (2022) Frontiers in Pharmacology doi: 10.3389\/fphar.2022.835081.<\/span>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row content_placement=\u00a0\u00bbmiddle\u00a0\u00bb parallax=\u00a0\u00bbcontent-moving\u00a0\u00bb css=\u00a0\u00bb.vc_custom_1698847106223{margin-top: -50px !important;padding-top: 0px !important;padding-bottom: 100px !important;background-position: center;background-repeat: no-repeat !important;background-size: cover !important;}\u00a0\u00bb][vc_column][vc_single_image image=\u00a0\u00bb741&Prime; img_size=\u00a0\u00bbfull\u00a0\u00bb onclick=\u00a0\u00bbcustom_link\u00a0\u00bb css=\u00a0\u00bb\u00a0\u00bb link=\u00a0\u00bbhttp:\/\/www.montdorex.com\/fr\/publications\u00a0\u00bb][info_banner_vc google_fonts=\u00a0\u00bbfont_family:Abril%20Fatface%3Aregular|font_style:400%20regular%3A400%3Anormal\u00a0\u00bb image_id=\u00a0\u00bb577&Prime;][\/info_banner_vc][vc_column_text]\u00c9tablie \u00e0 Montr\u00e9al, au Canada, Montdorex Inc. est une &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/pages\/605"}],"collection":[{"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/comments?post=605"}],"version-history":[{"count":9,"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/pages\/605\/revisions"}],"predecessor-version":[{"id":742,"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/pages\/605\/revisions\/742"}],"wp:attachment":[{"href":"https:\/\/montdorex.com\/fr\/wp-json\/wp\/v2\/media?parent=605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}